© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Two challenges to the very possibility of emergence are addressed, one metaphysical and one logical. The resolution of the metaphysical challenge requires a shift to a process metaphysics, while the logical challenge highlights normative emergence, and requires a shift to more powerful logical tools -- in particular, that of implicit definition. Within the framework of a process metaphysics, two levels of normative emergence are outlined: that of function and that of representation.

This article focuses on the problem of representational content. Accounting for representational content is the central issue in contemporary naturalism: it is the major remaining task facing a naturalistic conception of the world. Representational content is also the central barrier to contemporary cognitive science and artificial intelligence: it is not possible to understand representation in animals nor to construct machines with genuine representation given current (lack of) understanding of what representation is. An elaborated critique is offered to current approaches to (...) representation, arguing that the basic underlying approach is, at root, logically incoherent, and, thus, that standard approaches are doomed to failure. An alternative model of representation - interactivism - is presented that avoids or solves the problems facing standard approaches. Interactivism is framed by a version of functionalism, and a naturalization of that functionalism completes an outline of a naturalization of representation and representational content. (shrink)

Operational definitions were a neo-Machean development that connected with the positivism of Logical Positivism. Logical Positivism failed, with the failure of operational definitions being just one of multiple and multifarious failures of Logical Positivism more broadly. Operationalism, however, has continued to seduce psychology more than half a century after it was repudiated by philosophers of science, including the very Logical Positivists who had first taken it seriously. It carries with it a presupposed metaphysics that is false in virtually all of (...) its particulars, and thereby distorts and obscures genuine issues concerning the nature of theory and of science. It makes it particularly difficult for psychologists, under the thrall of this dogma, to free themselves from these false presuppositions, and to think about, create, and critique genuine scientific theory and process. That is the tragedy of operationalism. (shrink)

I will argue that mechanism is not sufficient to capture representation, thus cognition. More generally, mechanism is not sufficient to capture normativity of any sort. I will also outline a model of emergent normativity, representational normativity in particular, and show how it transcends these limitations of mechanism. To begin, I will address some illustrative attempts to model representation within mechanistically naturalistic frameworks, first rather generally, and then in the cases of the models of Fodor and Millikan.

Internal relations are those relations that are intrinsic to the nature of one or more of the relata. They are a kind of essential relation, rather than an essential property. For example, an arc of a circle is internally related to the center of that circle in the sense that.

We all believe an unbounded number of things about the way the world is and about the way the world works. For example, I believe that if I move this book into the other room, it will not change color -- unless there is a paint shower on the way, unless I carry an umbrella through that shower, and so on; I believe that large red trucks at high speeds can hurt me, that trucks with polka dots can hurt me, (...) and so on; that if I move this book, the room will stay in place -- unless there is a pressure switch under the book attached to a bomb, unless the switch communicates to the bomb by radio and there is shielding in the way, and so on; that the moon is not made of green cheese, that the moon is not made of caviar, that the moon is not made of gold, and so on. The problems involved in accounting for such infinite proliferations of beliefs -- and the computations and inferences that take them into account -- are collectively called the Frame Problems, and are considered by some to constitute a major discovery of a new philosophical problem. How could we possibly learn them all? How could the brain possibly hold them all? The problems appear insoluble, impossible. Yet we all learn and hold such unbounded numbers of beliefs; in particular, children do. Something must be wrong. I wish to argue that the frame problem arises from a fundamental presupposition about the nature of representation -- a false presupposition. Yet, it is a presupposition that dominates contemporary developmental psychology (and psychology more broadly, and cognitive science, artificial intelligence, philosophy of mind, and so on). In particular, I will offer an alternative model of the nature of representation within which the frame problem does not arise -- within which such unboundedness is natural. (shrink)

Function emerges in certain kinds of far-from-equilibrium systems. One important kind of function is that of interactive anticipation, an adaptedness to temporal complexity. Interactive anticipation is the locus of the emergence of normative representational content, and, thus, of representation in general: interactive anticipation is the naturalistic core of the evolution of cognition. Higher forms of such anticipation are involved in the subsequent macro-evolutionary sequence of learning, emotions, and reflexive consciousness.

In the last hundred years, the philosophy of natural law has suffered a fate that could hardly have been envisaged by the seventeenth and eighteenth century exponents of its universality and eternity: it has become old-fashioned. The positivists and the Marxists were happy to throw eternal moral ity out of the window, confident that some magic temporal harmony would eventually follow Progress in by the front door. Their hopes may not have been fully realized, but they did succeed in discrediting (...) natural law. What is often not appreciated is the extent to which we have adopted the tenets of the philosophy they despised, borh in the field of politics, and in the field of personal and social ethics, which Barbeyrac called "la science des mreurs" and which the positivists re christened "social science". Consequently, though we live in a world whose freedom, such as it is, is largely a result of the popularization of the philosophy of natural law, and whose conscious and unconscious standards, such as they are, are a result of that philosophy as it became combined with Christianity, the doctrine of natural law is itself for gotten. In view of the oblivion into which it has fallen, natural law is a concept which means little to the average reader. All too often, Montesquieu scholars have traded on this oblivion in order to give an exaggerated picture of his originality. (shrink)

The dominant assumptions -- throughout contemporary philosophy, psychology, cognitive science, and artificial intelligence -- about the ontology underlying intentionality, and its core of representationality, is that of encodings -- some sort of informational or correspondence or covariation relationship between the represented and its representation that constitutes that representational relationship. There are many disagreements concerning details and implementations, and even some suggestions about claimed alternative ontologies, such as connectionism (though none that escape what I argue is the fundamental flaw in these (...) dominant approaches). One assumption that seems to be held by all, however, usually without explication or defense, is that there is _one_ singular underlying ontology to representationality. In this paper, I argue that there are in fact quite a number of ontologies that manifest representationality -- levels of representationality -- and that _none_ of them are the standard "manipulations of encoded symbols" ontology, nor any other variation on the informational approach to representation. Collectively, these multiple representational ontologies constitute a framework for cognition, whether natural or artificial. (shrink)

A debate has simmered concerning the nature of clinical reasoning, especially diagnostic reasoning: Is it a “science” or an “art”? The trend since the seventeenth century has been to regard medical reasoning as scientific reasoning, and the most advanced clinical reasoning is the most scientific. However, in recent years, several scholars have argued that clinical reasoning is clearly not “science” reasoning, but is in fact a species of narratival or hermeneutical reasoning. The study reviews this dispute, and argues that in (...) a theoretical sense, the dispute rests upon a naïve—but very popular—caricature of what constitutes “science reasoning.” But, if the dispute rests upon just such a caricature, why is it so persistent? The study concludes by suggesting that we, as patients and as physicians, have deep psychological tendencies that incline us to adopt the very naïve “science” concept/model of diagnostic reasoning, even if (or when) we understand its inaptness. (shrink)

Several research groups have identified a network of regions of the adult cortex that are activated during social perception and cognition tasks. In this paper we focus on the development of components of this social brain network during early childhood and test aspects of a particular viewpoint on human functional brain development: “interactive specialization.” Specifically, we apply new data analysis techniques to a previously published data set of event-related potential ~ERP! studies involving 3-, 4-, and 12-month-old infants viewing faces of (...) different orientation and direction of eye gaze. Using source separation and localization methods, several likely generators of scalp recorded ERP are identified, and we describe how they are modulated by stimulus characteristics. We then review the results of a series of experiments concerned with perceiving and acting on eye gaze, before reporting on a new experiment involving young children with autism. Finally, we discuss predictions based on the atypical emergence of the social brain network. (shrink)

Biosemiotics contains at its core fundamental issues of naturalism: are normative properties, such as meaning, referent, and others, part of the natural world, or are they part of a second, intentional and normative, metaphysical realm — one that might be analogically applied to natural phenomena, such as within biological cells — but a realm that nevertheless remains metaphysically distinct? Such issues are manifestations of a fundamental metaphysical split between a “natural” realm and a realm of normativity and intentionality. This problematic (...) metaphysical split derives from conceptual problems originating with the Pre-Socratics; transcending that split requires correcting those problems. In particular, transcending that split requires a model of metaphysical emergence, and, in particular, normative emergence. This paper will limn that argument regarding metaphysical emergence, but focus most strongly on an overview of a model of normative, representational emergence that overcomes that metaphysical diremption. (shrink)

The principle of gratuitous suffering -- The value of humans and the value of animals -- The holocaust of factory farming -- Hunting -- Animal experimentation -- The law and animals -- Women and animals.

A national survey on researchers’ experiences with their institutional review boards (IRBs) is presented, focused exclusively on social and behavioral researchers. A wide range of experiences is apparent in the data, especially in terms of turnaround time for submitted protocols, incidence of data collection without prior IRB approval, and stated reasons for "going solo." Sixty-two percent felt that the turnaround time they typically experience is "reasonable," and 44% said they had not experienced long delays in obtaining approval. However, 48% of (...) respondents reported either conducting a project without IRB approval or modifying an existing project without IRB approval, with anticipated time for approval being the dominant reason offered for doing so. This adds a new dimension to the widely discussed "national IRB crisis" (e.g., Illinois White Paper, 2005). The article concludes with 2 preliminary recommendations for IRB reform. (shrink)

The interactivist model has explored a number of consequences of process metaphysics. These include reversals of some fundamental metaphysical assumptions dominant since the ancient Greeks, and multiple further consequences throughout the metaphysics of the world, minds, and persons. This article surveys some of these consequences, ranging from issues regarding entities and supervenience to the emergence of normative phenomena such as representation, rationality, persons, and ethics.

In this fresh and powerfully argued book, Mark Bernstein identifies the qualities that make an entity deserving of moral consideration. It is frequently assumed that only (normal) human beings count. Bernstein argues instead for "experientialism"--the view that having conscious experiences is necessary and sufficient for moral standing. He demonstrates that this position requires us to include many non-human animals in our moral realm, but not to the extent that many deep ecologists champion.

Emergence seems necessary for any naturalistic account of the world — none of our familiar world existed at the time of the Big Bang, and it does now — and normative emergence is necessary for any naturalistic account of biology and mind — mental phenomena, such as representation, learning, rationality, and so on, are normative. But Jaegwon Kim’s argument appears to render causally efficacious emergence impossible, and Hume’s argument appears to render normative emergence impossible, and, in its general form, it (...) precludes any emergence at all. I argue that both of these barriers can be overcome, and, in fact, that they each constitute reductios of their respective underlying presuppositions. In particular, causally efficacious ontological emergence can be modeled, but only within a process metaphysics, thus avoiding Kim’s argument, and by making use of non-abbreviatory forms of definition, thus avoiding Hume’s argument. I illustrate these points with models of the emergent nature of normative function and of representation. (shrink)

Persons are biological beings who participate in social environments. Is human sociality different from that of insects? Is human sociality different from that of a computer or robot with elaborate rules for social interaction in its program memory? What is the relationship between the biology of humans and the sociality of persons? I argue that persons constitute an emergent ontological level that develops out of the biological and psychological realm, but that is largely social in its own constitution. This requires (...) a characterization of the relationships between the bio/psychological and the social, and of the developmental process of emergence. It also requires a framework for modeling the bio/psychological level that makes any such emergence possible. Neither attachment theory nor information processing frameworks, for example, will do — the major orientations toward human sociality today make understanding that sociality ultimately impossible. Only an action framework, such as that of Peirce or Piaget2, suffices. (shrink)

neglected aspect: knowledge of error, or ‘‘negative’’ knowledge. The development of knowledge of what counts as error occurs via a kind of internal variation and selection, or quasi-evolutionary, process. Processes of reflection generate a hierarchy of principles of error.

* This paper was to have been written jointly with Don Campbell. His tragic death on May 6, 1996, occurred before we had been able to do much planning for the paper. As a result, this is undoubtedly a very different paper than if Don and I had written it together, and, undoubtedly, not as good a paper. Nevertheless, I believe it maintains at least the spirit of what we had discussed. Clearly, all errors are mine alone.

How Does the Environment Affect the Person? Mark H. Bickhard invited chapter in Children's Development within Social Contexts: Metatheoretical, Theoretical and Methodological Issues, Erlbaum. edited by L. T. Winegar, J. Valsiner, in press.

In "Size Matters" in this issue, Joel MacClellan argues for three claims: according to utilitarianism, faced with a choice of eating large or small animals, we should eat the large; utilitarianism may ground obligations to eat meat; and we justifiably attract greater moral responsibility for the "direct" killing of our food animals than we do for "indirect" killing. MacClellan tends to underestimate the resources available even to hedonistic utilitarianism and oversimplifies the conditions in the food industry. His second claim has (...) merit but is merely an instance of utilitarianism’s problem with providing a satisfying account of justice. (shrink)

In this paper I wish to address the question of the nature of psychopathology. It might naturally be felt that we already know a great deal about psychopathology, and thus that such a paper would be primarily a review and discussion of the literature; I will argue, however, that the most fundamental form of the question concerning the nature of psychopathology is rarely posed in the literature, that it is prevented from being posed by presuppositions inherent in standard theoretical approaches, (...) and that, on those rare occasions when it does get addressed, it has received inadequate answers. Therefore, the paper will have more of the character of a conceptual explication and theoretical exegesis than it will of a review of the literature. (shrink)

Standard semantic information processing models—information in; information processed; information out —lend themselves to standard models of the functioning of the brain in terms, e.g., of threshold-switch neurons connected via classical synapses. That is, in terms of sophisticated descendants of McCulloch and Pitts models. I argue that both the cognition and the brain sides of this framework are incorrect: cognition and thought are not constituted as forms of semantic information processing, and the brain does not function in terms of passive input (...) processing units organized as neural nets. An alternative framework is developed that models cognition and thought not in terms of semantic information processing, and, correspondingly, models brain functional processes also not in terms of semantic information processing. As alternative to such models: I outline a pragmatist oriented, interaction based, model of representation; derive from this model a fundamental framework of constraints on how the brain must function; show that such a framework is in fact found in the brain, and develop the outlines of a broader model of how mental processes can be realized within this alternative framework. Part I of this discussion focuses on some criticisms of standard modeling frameworks for representation and cognition, and outlines an alternative interactivist, pragmatist oriented, model. In part II, the focus is on the fact that the brain does not, in fact, function in accordance with standard passive input processing models—e.g., information processing models. Instead, there are multiple endogenously active processes at multiple spatial and temporal scales across multiple kinds of cells. A micro-functional model that accounts for, and even predicts, these multi-scale phenomena in generating emergent representation and cognition is outlined. That is, I argue that the interactivist model of representation outlined offers constraints on how the brain should function that are in fact empirically found, and, in reverse, that the multifarious details of brain functioning entail the pragmatist representational model—a very strong interrelationship. In the sequel paper, starting with part III, this model is extended to address macro-functioning in the CNS. In part IV, I offer a discussion of an approach to brain functioning that has some similarities with, as well as differences from, the model presented here: sometimes called the predictive brain approach. (shrink)